Blood donations save human lives and can help get medication to patients safely. Sanquin uses immune cells taken from donor blood to investigate the safety of medicines.
Biotherapeutics are widely used and present a promising solution to many diseases. Their concentration in blood, their longevity and the effective dose need to be monitored to ensure a safe dose range and to confirm efficacy. Sanquin PBS is a key opinion leader in the field and has developed and provided quality biotherapeutic assays for decades.
Just because a cell is difficult to work with doesn’t mean that it should be excluded from quality, safety, or efficacy controls. Through its vast experience and an optimized workflow, Sanquin PBS can study all aspects of difficult-to-handle blood cells including phagocytosis, degranulation, NETosis, migration, cytokine release, and apoptosis.
Whole blood assays can measure direct and indirect drug interactions in a setup that reflects the natural environment in the body, catching any unforeseen effects that usually materialize later in the pipeline. Sanquin PBS is one of the few partners worldwide that can screen compounds on a large scale in whole blood for e.g. cytokine production, or complement activation.